Volume 5, Issue 6, December 2017, Page: 110-113
Synthesis, Characterization and Antifungal Activity of Manganese (II) Complex with Schiff Base Derived from Acetylacetone and Leucine
Aishatu Salihu Mohammed, Department of Applied Science, Kaduna Polytechnic, Kaduna, Nigeria
Fatima Abubakar, Department of Applied Science, Kaduna Polytechnic, Kaduna, Nigeria
Abigail Ebi Aye, Department of Applied Science, Kaduna Polytechnic, Kaduna, Nigeria
Received: Oct. 20, 2017;       Accepted: Nov. 3, 2017;       Published: Dec. 22, 2017
DOI: 10.11648/j.nano.20170506.15      View  1678      Downloads  100
Abstract
This study was aimed at synthesizing, characterizing and evaluating the antifungal activity of the Schiff base and Mn (II) complex. The reaction of the mixture of ethanol solution of acetylacetone and leucine yielded a Schiff base. The interaction between the Schiff base in hot aqueous methanol mixture and manganese (II) chloride in ethanol gave the manganese (II) Schiff base complex. The complex was characterized by decomposition/melting point temperatures, solubility test, IR spectrophotometry, colour determination, dissociation constant of Schiff base and antifungal activity. The Schiff base obtained has yellow colour, with a melting point of 250°C and percentage yield of 54.67% while the manganese (II) complex obtained had a pink colour with decomposition temperature of 167°C and percentage yield of 76.40%. The Schiff base and the complex was soluble in some solvents but slightly soluble in others. The Infrared spectra of the Schiff base showed a band at a range of 1600cm-1 - 1622cm-1 attributed to v (C=N) stretching frequencies establishing it being a Schiff base. Similar bands were observed in the spectra of Manganese (II) Schiff base complex but in lower frequencies indicating that the Schiff base has coordinated to the Mn ion. The antifungal activity of manganese (II) complex showed significant activity on the fungal isolates Candida albican and Sacchromyces cerevisiae. The study concludes that Schiff base synthesized was a weak acid and the Schiff base was not an active drug against the fungal pathogens used but Mn (II) complex was active against the pathogens used.
Keywords
Antifungal, C. albican, Infrared, Manganese (II), Schiff Base, S. cerevisiae
To cite this article
Aishatu Salihu Mohammed, Fatima Abubakar, Abigail Ebi Aye, Synthesis, Characterization and Antifungal Activity of Manganese (II) Complex with Schiff Base Derived from Acetylacetone and Leucine, American Journal of Nano Research and Applications. Vol. 5, No. 6, 2017, pp. 110-113. doi: 10.11648/j.nano.20170506.15
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
ZH Chohan, M Arif, ZH Akhtar and ST Claudiu. Synthesis, Characterization and Antimicrobial activity of Cobalt metal complex against multi-resistant bacterial and fungal pathogens. Bioinorganic Chemistry and Applications Journal, 2 (6), 2006, 1-13.
[2]
K David and H Henderson, Biological history of microorganism. American Journal of Infection Control, 34, 2006. 46-56.
[3]
D Jeffery. The remarkable story of a wonder drug. Journal of Aspirin. 25 (3), 2005, 50-98.
[4]
A Kimberly, C Nicholas, C Nathaniel and L Anderson. Substituent effects on Keto-Enol Equilibria using NMR Spectroscopy. Journal of Chemical Education, 88 (10), 2011, 1444-1445.
[5]
PA Vigato and S Tamburini. Schiff base: a review of its properties. Journal of Co-ordination Chemistry, 2 (1), 2004, 17.
[6]
F Lebon, N Boggeto and M Lebeca. Metal organic commands a new approach for drug discovery: N -1, 2, 3, 6 - trimethoxy benzamide copper (II) complex as an inhibitor of human immunodeficiency virus protease, Biochemical Pharmacology Journal, 63 (10), 2002, 1863-1873.
[7]
OW Salawu, PK Onoja and JF Saleh. Chemical properties of compounds. J. Der Chemical Sinica, 2 (5), 2011, 25.
[8]
SW Hassan, RA Umar and M Lawal. Evaluation of antifungal activity of Ficus sycomorus L. (moraceae). Best Journal 3 (2), 2006, 18-25.
[9]
J Rosenthal, L Combaret and MR Etzel. Metabolic fate of Leucine: A significant sterol precursor in Adipose tissue and Muscle. American Journal of Physiology, 226 (2), 2008, 411-418.
[10]
M Ul-Hassan, ZH Chohan, A Scozzafava and CT Supuran. Schiff bases of aromatic and heterocyclic sulfonamides and their metal complexes. Journal of Enzyme Inhibition and Medicinal Chemistry. 19 (3), 2004, 263-267.
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